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1

Histone deacetylase inhibitors and cancer: from cell biology to the clinic

Holger Hess-Stumpp

Journal:

European Journal of Cell Biology

Year:

2005

Language:

english

File:

PDF, 336 KB

english, 2005

2

Asoprisnil (J867): a selective progesterone receptor modulator for gynecological therapy

Deborah DeManno, Walter Elger, Ramesh Garg, Ronald Lee, Birgitt Schneider, Holger Hess-Stumpp, Gerd Schubert, Kristof Chwalisz

Journal:

Year:

2003

Language:

english

File:

PDF, 698 KB

english, 2003

3

Mass cytometry analysis reveals a distinct immune environment in peritoneal fluid in endometriosis: a characterisation study

Guo, Manman, Bafligil, Cemsel, Tapmeier, Thomas, Hubbard, Carol, Manek, Sanjiv, Shang, Catherine, Martinez, Fernando O., Schmidt, Nicole, Obendorf, Maik, Hess-Stumpp, Holger, Zollner, Thomas M., Kenne

Journal:

Year:

2020

Language:

english

File:

PDF, 2.63 MB

english, 2020

4

PTK 787/ZK 222584, a Tyrosine Kinase Inhibitor of all Known VEGF Receptors, Represses Tumor Growth with High Efficacy

Holger Hess-Stumpp, Martin Haberey, Karl-Heinz Thierauch

Journal:

Year:

2005

Language:

english

File:

PDF, 214 KB

english, 2005

5

ChemInform Abstract: Synthesis and Biological Activity of a Novel, Highly Potent Progesterone Receptor Antagonist.

Ulrike Fuhrmann, Holger Hess-Stumpp, Arwed Cleve, Guenter Neef, Wolfgang Schwede, Jens Hoffmann, Karl-Heinrich Fritzemeier, Kristof Chwalisz

Journal:

Year:

2001

File:

PDF, 30 KB

2001

6

Therapy of thyroid carcinoma with the histone deacetylase inhibitor MS-275

Annette Altmann, Michael Eisenhut, Ulrike Bauder-Wüst, Annette Markert, Vasileios Askoxylakis, Holger Hess-Stumpp, Uwe Haberkorn

Journal:

European Journal of Nuclear Medicine and Molecular Imaging

Year:

2010

Language:

english

File:

PDF, 408 KB

english, 2010

7

LDH-Ainfluences hypoxia-inducible factor 1α (HIF1 α) and is critical for growth of HT29 colon carcinoma cells in vivo

Stefan Langhammer, Maher Najjar, Holger Hess-Stumpp, Karl-Heinz Thierauch

Journal:

Targeted Oncology

Year:

2011

Language:

english

File:

PDF, 494 KB

english, 2011

8

Cycle-dependent endometrial expression and hormonal regulation of the fibulin-1 gene

Bernard Haendler, Hiroshi Yamanouchi, Bruce A. Lessey, Kristof Chwalisz, Holger Hess-Stumpp

Journal:

Molecular Reproduction and Development

Year:

2004

Language:

english

File:

PDF, 230 KB

english, 2004

9

MS-275, a potent orally available inhibitor of histone deacetylases—The development of an anticancer agent

Holger Hess-Stumpp, Tomke Ute Bracker, David Henderson, Oliver Politz

Journal:

The International Journal of Biochemistry & Cell Biology

Year:

2007

Language:

english

File:

PDF, 694 KB

english, 2007

10

A nude mice model for the investigation of peritoneal endometriosis

P.-A. Regidor, K. Bainczyk, H. Hess-Stumpp, R. Grummer, E. Winterhager, A.E. Shindler

Journal:

International Journal of Gynecology & Obstetrics

Year:

2000

Language:

english

File:

PDF, 326 KB

english, 2000

11

Antiproliferative effects of progesterone antagonists and progesterone receptor modulators on the endometrium

Kristof Chwalisz, Robert M Brenner, Ulrike U Fuhrmann, Holger Hess-Stumpp, Walter Elger

Journal:

Year:

2000

Language:

english

File:

PDF, 553 KB

english, 2000

12

59 Comparison of the efficacy of MS-275, Cl-994 and SAHA in vivo in various experimental tumor models after oral application

H. Hess-Stumpp, D. Grossbach, P. Lienau

Journal:

European Journal of Cancer Supplements

Year:

2004

Language:

english

File:

PDF, 293 KB

english, 2004

13

82 MS-275, a potent orally active inhibitor of histone deacetylases is highly active in experimental tumor models of melanoma and prostate cancer

H. Hess-Stumpp, J. Hoffmann, A. Schott

Journal:

European Journal of Cancer Supplements

Year:

2004

Language:

english

File:

PDF, 147 KB

english, 2004

14

155 PTK787/ZK 222584 (PTK/ZK), a potent orally active and highly selective inhibitor of VEGFR kinases, is highly efficacious in various experimental tumor models either as mono- or combination therapy

H. Hess-Stumpp, M. Haberey, A. Reichel, K.H. Thierauch

Journal:

European Journal of Cancer Supplements

Year:

2004

Language:

english

File:

PDF, 145 KB

english, 2004

15

P48 Progesterone receptor antagonists an alternative for breast cancer prevention

J. Hoffmann, R.B. Lichtner, U. Fuhrmann, H. Hess-Stumpp, G. Siemeister, A. Cleve, G. Neef, K. Parczyk, M.R. Schneider, K. Bosslet

Journal:

European Journal of Cancer Supplements

Year:

2004

Language:

english

File:

PDF, 130 KB

english, 2004

16

49 POSTER Experimental tumor models with high LDH activity are efficiently targeted by treatment with PTK787/ZK222584, an oral multi-VEGF tyrosine kinase inhibitor

H. Hess-Stumpp, K.H. Thierauch, B. Riefke, C. Schnell, A. Littlewood-Evans

Journal:

European Journal of Cancer Supplements

Year:

2006

Language:

english

File:

PDF, 88 KB

english, 2006

17

LDH-A gene suppression affects cell growth of colon carcinoma xenografts but not in culture conditions

S. Langhammer, M. Najjar, K. Berhoerster, H. Hess-Stumpp, K.H. Thierauch

Journal:

European Journal of Cancer Supplements

Year:

2008

Language:

english

File:

PDF, 98 KB

english, 2008

18

152 The novel highly selective and efficacious MET inhibitor BAY853474: mode of action, basic in vitro characteristics and preclinical pharmacology

D. Zopf, M. Kissel, M. Mamounas, K. Schuck, G. Fachinger, U. Bömer, H. Hess-Stumpp, P. Lienau, S. Ince

Journal:

European Journal of Cancer Supplements

Year:

2010

Language:

english

File:

PDF, 63 KB

english, 2010

19

207 A novel selective MET inhibitor combined with erlotinib overcomes erlotinib facilitated resistance in patient derived NSCLC xenografts in vivo

M. Kissel, T. Müller, I. Fichtner, H. Hess-Stumpp

Journal:

European Journal of Cancer Supplements

Year:

2010

Language:

english

File:

PDF, 60 KB

english, 2010

20

Synthesis and Biological Activity of a Novel, Highly Potent Progesterone Receptor Antagonist

Fuhrmann, Ulrike, Hess-Stumpp, Holger, Cleve, Arwed, Neef, Günter, Schwede, Wolfgang, Hoffmann, Jens, Fritzemeier, Karl-Heinrich, Chwalisz, Kristof

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 76 KB

english, 2000

21

Inhibition of Hypoxia-Induced Gene Transcription by Substituted Pyrazolyl Oxadiazoles: Initial Lead Generation and Structure-Activity Relationships

Härter, Michael, Thierauch, Karl-Heinz, Boyer, Stephen, Bhargava, Ajay, Ellinghaus, Peter, Beck, Hartmut, Greschat-Schade, Susanne, Hess-Stumpp, Holger, Unterschemmann, Kerstin

Journal:

Year:

2014

Language:

english

File:

PDF, 344 KB

english, 2014

22

Hypoxia-Inducible Factor Pathway Inhibition Resolves Tumor Hypoxia and Improves Local Tumor Control After Single-Dose Irradiation

Helbig, Linda, Koi, Lydia, Brüchner, Kerstin, Gurtner, Kristin, Hess-Stumpp, Holger, Unterschemmann, Kerstin, Pruschy, Martin, Baumann, Michael, Yaromina, Ala, Zips, Daniel

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

2014

Language:

english

File:

PDF, 1.07 MB

english, 2014

23

Sagopilone crosses the blood-brain barrier in vivo to inhibit brain tumor growth and metastases

Hoffmann, J., Fichtner, I., Lemm, M., Lienau, P., Hess-Stumpp, H., Rotgeri, A., Hofmann, B., Klar, U.

Journal:

Year:

2008

Language:

english

File:

PDF, 6.02 MB

english, 2008

24

Inhibition of Multiple Vascular Endothelial Growth Factor Receptors (VEGFR) Blocks Lymph Node Metastases but Inhibition of VEGFR-2 Is Sufficient to Sensitize Tumor Cells to Platinum-Based Chemotherapeutics

Sini, P., Samarzija, I., Baffert, F., Littlewood-Evans, A., Schnell, C., Theuer, A., Christian, S., Boos, A., Hess-Stumpp, H., Foekens, J. A., Setyono-Han, B., Wood, J., Hynes, N. E.

Journal:

Cancer Research

Year:

2008

Language:

english

File:

PDF, 1.28 MB

english, 2008

25

BAY 87–2243, a novel inhibitor of hypoxia-induced gene activation, improves local tumor control after fractionated irradiation in a schedule-dependent manner in head and neck human xenografts

Helbig, Linda, Koi, Lydia, Brüchner, Kerstin, Gurtner, Kristin, Hess-Stumpp, Holger, Unterschemmann, Kerstin, Baumann, Michael, Zips, Daniel, Yaromina, Ala

Journal:

Radiation Oncology

Year:

2014

Language:

english

File:

PDF, 1.25 MB

english, 2014

26

SIAH ubiquitin ligases regulate breast cancer cell migration and invasion independent of the oxygen status

Adam, M Gordian, Matt, Sonja, Christian, Sven, Hess-Stumpp, Holger, Haegebarth, Andrea, Hofmann, Thomas G, Algire, Carolyn

Journal:

Year:

2015

Language:

english

File:

PDF, 1.19 MB

english, 2015

27

Chronic progesterone antagonist-estradiol therapy suppresses breakthrough bleeding and endometrial proliferation in a menopausal macaque model

Slayden, O.D., Zelinski, M.B., Chwalisz, K., Hess-Stumpp, H., Brenner, R.M.

Journal:

Human Reproduction

Year:

2006

Language:

english

File:

PDF, 981 KB

english, 2006

28

Progesterone receptor antagonists (antiprogestins)

Hess-Stumpp, H., Hoffmann, J., Fuhrmann, U.

Journal:

Drugs of the Future

Year:

2002

Language:

english

File:

PDF, 151 KB

english, 2002

29

Pan-mutant-IDH1 inhibitor BAY1436032 is highly effective against human IDH1 mutant acute myeloid leukemia in vivo

Chaturvedi, A, Herbst, L, Pusch, S, Klett, L, Goparaju, R, Stichel, D, Kaulfuss, S, Panknin, O, Zimmermann, K, Toschi, L, Neuhaus, R, Haegebarth, A, Rehwinkel, H, Hess-Stumpp, H, Bauser, M, Bochtler,

Journal:

Year:

2017

Language:

english

File:

PDF, 34.02 MB

english, 2017

30

Acetyl-CoA Carboxylase 1-Dependent Protein Acetylation Controls Breast Cancer Metastasis and Recurrence

Rios Garcia, Marcos, Steinbauer, Brigitte, Srivastava, Kshitij, Singhal, Mahak, Mattijssen, Frits, Maida, Adriano, Christian, Sven, Hess-Stumpp, Holger, Augustin, Hellmut G., Müller-Decker, Karin, Naw

Journal:

Cell Metabolism

Year:

2017

Language:

english

File:

PDF, 5.23 MB

english, 2017

31

Discovery of Rogaratinib (BAY 1163877): a pan-FGFR Inhibitor

Collin, Marie-Pierre, Lobell, Mario, Hübsch, Walter, Brohm, Dirk, Schirok, Hartmut, Jautelat, Rolf, Lustig, Klemens, Bömer, Ulf, Vöhringer, Verena, Héroult, Mélanie, Grünewald, Sylvia, Hess-Stumpp, Ho

Journal:

Year:

2018

Language:

english

File:

PDF, 892 KB

english, 2018